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Marc Blondel Selected Research

Guanabenz (BR 750)

10/2014Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost α2-adrenergic receptor agonistic activity.
1/2011Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy.
9/2008Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells.
5/2008Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs.

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Marc Blondel Research Topics

Disease

8Neoplasms (Cancer)
01/2020 - 04/2014
4Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 07/2011
4Neurodegenerative Diseases (Neurodegenerative Disease)
01/2020 - 01/2006
3Prion Diseases (Transmissible Spongiform Encephalopathies)
01/2021 - 01/2006
3Proteostasis Deficiencies
03/2017 - 08/2008
3Hypertension (High Blood Pressure)
10/2014 - 04/2008
2Oculopharyngeal Muscular Dystrophy
06/2011 - 01/2011
1Leigh Disease (Leigh's Disease)
01/2022
1Down Syndrome (Down's Syndrome)
12/2020
1Colonic Neoplasms (Colon Cancer)
12/2020
1Alcoholism (Alcohol Abuse)
12/2020
1Malaria
01/2020
1Brain Diseases (Brain Disorder)
01/2020
1Poisoning
10/2016
1Virus Diseases (Viral Diseases)
01/2015
1Benign Familial Pemphigus (Hailey Hailey Disease)
10/2014
1Neuropathy ataxia and retinitis pigmentosa
07/2011
1Nervous System Diseases (Neurological Disorders)
06/2010
1Cystic Fibrosis (Mucoviscidosis)
09/2008
1Alzheimer Disease (Alzheimer's Disease)
01/2006

Drug/Important Bio-Agent (IBA)

6PrionsIBA
03/2017 - 01/2006
4Proteins (Proteins, Gene)FDA Link
01/2019 - 01/2006
4Guanabenz (BR 750)FDA Link
10/2014 - 05/2008
3Pharmaceutical PreparationsIBA
12/2020 - 05/2008
3Messenger RNA (mRNA)IBA
11/2018 - 01/2017
3Adenosine Triphosphate (ATP)IBA
12/2014 - 06/2010
2Amyloid (Amyloid Fibrils)IBA
06/2011 - 01/2006
26-aminophenanthridineIBA
01/2011 - 05/2008
1oligomycin sensitivity-conferring protein (complex V)IBA
01/2022
1Prion ProteinsIBA
01/2021
1Disulfiram (Antabuse)FDA Link
12/2020
1Aldehyde DehydrogenaseIBA
12/2020
1CopperIBA
12/2020
1Ditiocarb (Sodium Diethyldithiocarbamate)FDA Link
12/2020
1Staphylococcal Protein A (Protein A)IBA
01/2020
1Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA
01/2020
1artemisinin (artemisinine)IBA
01/2020
1fipronilIBA
01/2020
1NucleolinIBA
11/2018
1Peptides (Polypeptides)IBA
04/2018
1Protein Isoforms (Isoforms)IBA
10/2016
1Mitochondrial Proteins (Mitochondrial Protein)IBA
12/2014
1CalciumIBA
10/2014
1EpitopesIBA
04/2014
1EnzymesIBA
06/2010
1ChloridesIBA
09/2008
1Adrenergic Agonists (Adrenergic Receptor Agonist)IBA
09/2008
1Chloride Channels (Chloride Channel)IBA
09/2008
1Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
09/2008
1Biological ProductsIBA
08/2008

Therapy/Procedure

2Therapeutics
06/2015 - 01/2015